Motif ID: HOX{A4,D4}.p2

Z-value: 1.649


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4



Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_16380967 3.019 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr6_+_105511615 2.374 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr4_+_74491272 1.972 ALB
albumin
chr1_-_205161821 1.921 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr3_+_63928459 1.893 NM_001128149
ATXN7
ataxin 7
chr2_+_227900471 1.851 NM_020194
MFF
mitochondrial fission factor
chr13_-_40491405 1.656 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_+_165564904 1.593 NM_001198783
POU2F1
POU class 2 homeobox 1
chr12_+_69148120 1.590


chr5_+_67622242 1.533 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_165565006 1.525 POU2F1
POU class 2 homeobox 1
chr2_-_180135559 1.458 NM_001113398
ZNF385B
zinc finger protein 385B
chr22_+_19458378 1.442 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr13_-_40491491 1.363 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_-_121883647 1.309 HGD
homogentisate 1,2-dioxygenase
chr17_-_53849888 1.298 RNF43
ring finger protein 43
chr2_+_183290912 1.261 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr11_-_118405288 1.247 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr20_-_33706532 1.236 RBM12
RNA binding motif protein 12
chr4_+_100714995 1.190 MTTP
microsomal triglyceride transfer protein
chr11_-_5321329 1.161 NM_001005567
OR51B5
olfactory receptor, family 51, subfamily B, member 5
chr5_-_168204430 1.145


chr12_-_10464308 1.145 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr15_-_75259714 1.113 PEAK1
NKF3 kinase family member
chr1_-_205272619 1.097 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr7_-_96471544 1.097 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr9_+_263025 1.065 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr1_-_114215768 1.030 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr1_+_149877955 0.989 SNX27
sorting nexin family member 27
chr10_-_69267774 0.954 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr19_+_17723285 0.945 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr11_-_117589283 0.943 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr16_+_56286212 0.940 NM_032269
CCDC135
coiled-coil domain containing 135
chr1_-_108032645 0.918 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_+_12728749 0.909 NM_152290
C1orf158
chromosome 1 open reading frame 158
chr12_+_52105131 0.903 AMHR2
anti-Mullerian hormone receptor, type II
chr6_-_116973465 0.900 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr6_+_6533932 0.900 NM_004271
LY86
lymphocyte antigen 86
chr17_-_36276987 0.897 NM_000223
KRT12
keratin 12
chr17_-_53849929 0.891 NM_017763
RNF43
ring finger protein 43
chr14_-_37133927 0.889 FOXA1
forkhead box A1
chr20_-_45410033 0.889 ZMYND8
zinc finger, MYND-type containing 8
chr4_-_123761615 0.888 NM_021803
IL21
interleukin 21
chr14_+_38804226 0.882 NM_203354
CTAGE5
CTAGE family, member 5
chr5_-_16791346 0.859 MYO10
myosin X
chr11_+_22644732 0.851 NM_001143830
GAS2
growth arrest-specific 2
chr17_-_36418869 0.839 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr20_+_42463419 0.837 HNF4A
hepatocyte nuclear factor 4, alpha
chr14_+_38772870 0.836 NM_054024
MIA2
melanoma inhibitory activity 2
chr12_+_53177789 0.826 NCKAP1L
NCK-associated protein 1-like
chr12_+_53177806 0.824 NCKAP1L
NCK-associated protein 1-like
chr7_+_106897737 0.823 NM_005295
GPR22
G protein-coupled receptor 22
chr10_+_86121526 0.820 FAM190B
family with sequence similarity 190, member B
chr6_+_64414389 0.815 NM_015153
PHF3
PHD finger protein 3
chr11_+_64694200 0.807 NM_001008778
SPDYC
speedy homolog C (Xenopus laevis)
chr11_+_73339011 0.792 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr3_-_52712639 0.778 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr17_-_36181927 0.777 NM_181539
KRT26
keratin 26
chr7_-_132371208 0.776 EEF1G
eukaryotic translation elongation factor 1 gamma
chr11_-_5227611 0.773 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr18_-_28606839 0.771 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr14_-_37134191 0.770 NM_004496
FOXA1
forkhead box A1
chr4_-_40212670 0.770 NM_019027
RBM47
RNA binding motif protein 47
chr17_+_50699965 0.766 HLF
hepatic leukemia factor
chr10_+_28918672 0.765 WAC
WW domain containing adaptor with coiled-coil
chr12_+_53177758 0.765 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr7_+_113853790 0.764 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr3_-_109730858 0.764 NM_014981
MYH15
myosin, heavy chain 15
chr5_+_140454382 0.762 NM_018936
PCDHB2
protocadherin beta 2
chr1_-_143708467 0.755 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_198643885 0.752 ZNF281
zinc finger protein 281
chr17_-_35975227 0.747 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr1_-_153537362 0.745 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr4_-_100070808 0.745 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr14_+_69306019 0.745 SRSF5
serine/arginine-rich splicing factor 5
chr11_-_46569489 0.741 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr12_-_101835510 0.737 NM_000277
PAH
phenylalanine hydroxylase
chr1_+_556968 0.730


chr5_-_132228375 0.725 NM_005260
GDF9
growth differentiation factor 9
chr1_-_36721501 0.720 NM_000760
NM_156039
NM_172313
CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr4_-_84254912 0.714 PLAC8
placenta-specific 8
chr5_+_171553780 0.712 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr16_+_10878539 0.711 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr4_-_84254873 0.709 PLAC8
placenta-specific 8
chr14_-_37134050 0.706 FOXA1
forkhead box A1
chr7_+_94953148 0.700 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr5_+_140546839 0.695 NM_019119
PCDHB9
protocadherin beta 9
chr14_+_87560646 0.690 LOC283587
hypothetical protein LOC283587
chr17_-_1195096 0.689 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr4_+_39874921 0.686 NM_004310
RHOH
ras homolog gene family, member H
chr6_+_64289585 0.682 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr20_-_10360569 0.676 NM_018848
MKKS
McKusick-Kaufman syndrome
chr4_-_84254932 0.674 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr20_+_42463350 0.671 HNF4A
hepatocyte nuclear factor 4, alpha
chr1_+_198263352 0.671 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr12_+_14429499 0.670 ATF7IP
activating transcription factor 7 interacting protein
chr9_+_94766379 0.668 FGD3
FYVE, RhoGEF and PH domain containing 3
chr16_+_29597829 0.668 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr11_-_102250876 0.662 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr22_-_25205376 0.660 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chrX_-_10761729 0.658 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chrX_-_137649180 0.654 NM_033642
FGF13
fibroblast growth factor 13
chr10_+_99488223 0.652 NM_001002261
ZFYVE27
zinc finger, FYVE domain containing 27
chr20_+_42463387 0.652 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_-_5130174 0.648 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr5_-_88155360 0.646 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_+_172530120 0.644 HAT1
histone acetyltransferase 1
chr11_-_83071084 0.643 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr10_-_101831579 0.642 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr3_+_63859114 0.638 NM_001177387
ATXN7
ataxin 7
chr3_-_74652952 0.636 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr12_+_53178834 0.630 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr1_+_54132447 0.624 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr6_-_32892705 0.616 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr21_+_29322100 0.613 USP16
ubiquitin specific peptidase 16
chr17_+_35148084 0.611 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr2_-_44440358 0.611 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr11_-_64520964 0.609 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr4_-_74704964 0.607 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr1_-_167947301 0.606 NM_000655
SELL
selectin L
chr20_+_42463279 0.604 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr9_+_109131814 0.603 RAD23B
RAD23 homolog B (S. cerevisiae)
chr4_+_74488835 0.602 NM_000477
ALB
albumin
chr2_-_165259334 0.601 COBLL1
COBL-like 1
chr4_+_106851415 0.600 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chrX_+_65300803 0.599 NM_001130860
NM_014799
HEPH

hephaestin

chr3_+_186529376 0.596 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chrX_-_13744933 0.595 GPM6B
glycoprotein M6B
chr19_+_50100843 0.592 NM_000041
APOE
apolipoprotein E
chr13_+_45174446 0.588 NM_152719
SPERT
spermatid associated
chr10_-_98311813 0.588 TM9SF3
transmembrane 9 superfamily member 3
chr15_-_32398220 0.584 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr12_-_120276394 0.583 NM_001137559
ANAPC5
anaphase promoting complex subunit 5
chr2_+_128119908 0.583 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr3_+_188222337 0.581 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr14_+_99555471 0.575 EVL
Enah/Vasp-like
chr3_-_121884091 0.570 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr1_-_158759606 0.570 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr19_+_4104593 0.566 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr12_-_121277972 0.566 NM_019887
NM_138929
DIABLO

diablo homolog (Drosophila)

chr14_-_94677807 0.558 NM_030621
DICER1
dicer 1, ribonuclease type III
chr2_+_170742900 0.558 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr4_+_74520796 0.557 NM_001134
AFP
alpha-fetoprotein
chr1_+_157067729 0.556 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr6_+_50789215 0.555 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr19_+_12810258 0.552 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr1_+_190811479 0.551 NM_002922
RGS1
regulator of G-protein signaling 1
chr17_-_78599695 0.551 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr2_+_127892489 0.551 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chrX_+_9391314 0.548 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr8_-_38324809 0.546 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr2_-_203484445 0.545 WDR12
WD repeat domain 12
chr5_-_134290789 0.542


chr9_-_122852356 0.542 NM_001735
C5
complement component 5
chr1_-_149004852 0.539 CTSS
cathepsin S
chr15_-_41664335 0.537 NM_014659
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr4_-_38460983 0.536 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr6_+_7524691 0.534 DSP
desmoplakin
chr1_+_159943385 0.533 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr9_-_103185621 0.531 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr6_+_79844267 0.530 PHIP
pleckstrin homology domain interacting protein
chr7_-_86433139 0.523 NM_152748
KIAA1324L
KIAA1324-like
chr2_+_143351695 0.520 KYNU
kynureninase
chr6_+_152053323 0.518 NM_001122742
ESR1
estrogen receptor 1
chr7_-_33047042 0.518 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr1_-_158815850 0.514 CD84
CD84 molecule
chr3_-_161584137 0.514 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr2_+_79593679 0.513 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr14_+_22859236 0.512 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chrX_-_116991728 0.509 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr17_-_46140015 0.507 NM_052855
ANKRD40
ankyrin repeat domain 40
chrX_-_11194015 0.507 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr3_+_173043832 0.504 NM_001164436
TMEM212
transmembrane protein 212
chr2_-_70166903 0.504 LOC400960
hypothetical LOC400960
chr18_+_29573152 0.504 ASXL3
additional sex combs like 3 (Drosophila)
chr3_+_173954940 0.502 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr1_-_158883666 0.502 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr12_+_99391870 0.500 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr19_-_40925151 0.500 NM_024660
TMEM149
transmembrane protein 149
chr15_-_74941339 0.500 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr22_+_24468110 0.497 NM_032608
MYO18B
myosin XVIIIB
chr6_-_138862271 0.493 NM_001144060
NHSL1
NHS-like 1
chr12_-_9777126 0.491 NM_172004
CLECL1
C-type lectin-like 1
chr2_+_73911477 0.491 STAMBP
STAM binding protein
chr6_-_138862273 0.490


chr16_-_56562512 0.489 NM_001135639
NM_001297
CNGB1

cyclic nucleotide gated channel beta 1

chr2_-_160765008 0.487 ITGB6
integrin, beta 6
chrX_-_153698930 0.486 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr3_+_1109619 0.486 NM_014461
CNTN6
contactin 6
chr7_+_18296569 0.485 HDAC9
histone deacetylase 9
chr12_-_4624536 0.485 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr22_-_36305883 0.485 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr2_+_127892459 0.484 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr10_-_43383912 0.477 NM_005674
ZNF239
zinc finger protein 239
chr2_-_55090759 0.475 NM_007008
RTN4
reticulon 4
chr2_+_218929822 0.475 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr1_+_205328834 0.474 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr2_+_171280182 0.474


chr9_-_85773899 0.469 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr12_-_10479810 0.468 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.